The Effect of Soya and Genistein Supplementation on Serum Lipid Profile of Male Dawley Sprague Rat

Background: Non-medical therapy is needed to reduce blood lipid levels and prevent atherosclerosis. Foods that contain Isoflavones can improve profiles in the blood.Aim: To determine effect of soya genistein supplementation various doses on total cholesterol, Low Density Lipoprotein (LDL), High (HDL), Triglycerides male Sprague-Dawley rats.Methods: 35 rats aged 6-8 weeks were divided into 7 groups, control group; low, medium, high soy milk; moderate, genistein. The treatment was given orally for 60 days. used mice with standard feed. On 61st day, hepatic tissue samples taken checked using Friedewald formula. Statistical analysis carried out by one-way ANOVA Tukey's posthoc test Dunnet test, then regression analysis.Results: There a significant increase cholesterol (p <0.05) Â LDL low moderate milk group compared all groups no differences HDL groups. Triglyceride Genistein genistein.Conclusion: Soya had increased Total Cholesterol, but